TL;DR: Has anyone with fructose malabsorption tried the current Soylent that uses Isomaltulose as an ingredient? How was your experience?
While very interested in trying Soylent, the use of Isomaltulose is currently stopping me since the ingredient is broken into equal parts of fructose and glucose mostly in the small intestine.
"Ingested isomaltulose is metabolised by the isomaltase-sucrase complex in the intestinal mucosa to equal parts glucose and fructose, which are readily absorbed and utilized in carbohydrate metabolic pathways…
… the hydrolysis and absorption of isomaltulose occurs almost completely in the small intestine."
However, it is also said that fructose absorption is facilitated when equal parts of fructose and glucose are consumed.
Of the two mechanisms involved in fructose absorption, the presence of glucose facilitates the transport of fructose across the brush-border membrane of the small intestine in the glucose-dependent fructose co-transport mechanism, thereby increasing the rate at which fructose is absorbed.
Observations from a small study (10 individuals only) point that individuals with possible malabsorption succesfully processed a whooping 50g of fructose that came in the form of 100g of sucrose (50% fructose, 50% glucose). Though the form of the sugar was in sucrose, not isomaltulose.
Yet, an assesment observed that Isomaltulose could cause problems for people with problems metabolizing fructose. The assesment talks only about people with HFI (Hereditary Fructose Intolerance) and people lacking the enzyme sucrase-isomaltase. It does not mention people with fructose malabsoption, but the website in itself mentions them.
"Is isomaltulose safe?
For most people, yes. However, a FSANZ safety assessment (pdf 403 kb) suggests it is unsuitable for people with disorders in fructose metabolism, such as hereditary fructose intolerance. As isomaltulose is broken down into fructose and glucose in the digestive tract, people with this condition are likely to experience severe adverse effects. Anyone with fructose malabsorption may also be affected."
Now, my worry here is whether the hydrolisis of isomaltulose breaks isomaltulose in equal parts at the same rate or whether there could be more parts from one substance (glucose/fructose) than the other at any time.
Has anyone with fructose malabsorption tried the current Soylent that uses Isomaltulose as an ingredient? How was your experience?