Modafinil ruled safe by FDA, possibly first cognitive enhancer


Modafinil could possibly be the first cognitive enhancer ruled safe by FDA.

Careful not to assume this covers adrafinil, as adrafinil has different metabolism and affects the liver differently.


I have tried Modafinil a few different times in the past and really couldn’t tell any difference in my alertness or cognitive ability.

Possible causes could have been that 1) it is something that is so subtle that I didn’t notice the effects, 2) the fact that I was taking it to be more alert in non-standard situations where alertness was needed and therefore was distracted and not able to adequately assess the effects, 3) that it affects different people differently and I am on the lower end of susceptibility, or 4) something else.


I can add that I used Adrafinil (which metabolizes into modafinil but is worse for the liver due to the process) and it worked well for me for driving but did not help my focus ability. Originally i got it to be able to drive (i frequently make long trips on the highway) but normally i feel like sleeping minutes into a highway drive. its not unusual for me to have 64 oz of monster per 6 hour drive and fall asleep right after. with adrafinil I needed no monster, but fell asleep like usual.


I’ve read the OD ceiling is kinda low. Could be wrong. For now I’ll stick with caffeine, noopepet and good ol’ cheeba.


It’s misleading to call Modafinil a cognitive enhancer and I think it’s a mistake to approach it that way. By that logic, ibuprofen is a cognitive enhancer when you have a headache. It’s merely relieving symptoms of a disorder: not sleeping well. Personally, I think it should really only be used regularly by people with inherent sleep disorders.


Do you know how I know you didn’t read the article?


when you are taking noopept anyway, why not take some DHA and choline ( choline preferably in the morning) as these both will provide raw materials for the nerve growth factor in noopept. Taking only noopept might not help that much. I dont remember but if by chance i have already told you this and you already ignored it, then ignore this comment :smile:


Lol you mentioned it before and don’t worry. I’ll pass on the choline. I thought about using something “natural” to accent my stack. Idk like Lion’s Mane or Ashwagandha or something? Probably unnecessary but eh might as well try it out.


Not ashwagandha but try using brahmi (a memory booster…well according to ayurveda anyway). Ofcourse the most expensive variety you can afford as cheaper kinds usually have more of other stuff added to them and less of brahmi.


Oh yea I hear this stuff has a lot of interesting effects. I’ll check it out thanks!


It’s likely that you’re a non-responder. One study found it works profoundly for most but hardly at all for a subset of people. (It’s not quit binary; it’s more like some are responders and some are barely-reponders.) But then one recent study author said his evidence showed it only works for those with “some sort of deficiency in creativity”

I am the same, disappointingly…doubly so since it would be quite useful for a sleep condition. The first day I get a very slight wakefulness boost along with an unusual headache, and a bit of a short temper. But it all could easily be placebo effet. And with physician orders I’ve gone up to 4x the max recommended dose with no further response.

This study is one of those that found non-responders. Those people had a met/met polymorphism of the COMT enzyme*. It’s only one study and it would be odd if this one polymorphism had this great of an effect. But interestingly, a couple years after seeing this study I found out I have that same met/met variation.

It’s an interesting hypothesis why: COMT is thought to control the level of dopamine; it’s function is, at least partially, to remove dopamine from the system. The met variation is the slower functioning variant, leading to higher dopamine. And the val variation–the alternative–is faster, leading to less dopamine hanging around. In very basic terms it could that modafinil increases dopamine such that a val/val or val/met individual is more like a val/val. The flip side of that would be the brains of met/met individuals are already functioning similarly to those who take modafinil. That’s my interpretation of the hypothesis anyways.


It sounds like you could have a sleep disorder. If insurance coverage isn’t an issue it wouldn’t be a bad idea to get checked out. Sleep disorders are a far more serious and prevalent issue than nearly anyone thinks.


I have a sleep disorder and cannot drive unless I am on my meds. Modafinil did not work for me. I am on nuvigil. My medicine costs $700/ month and insurance does not pay for it. I am currently working with a discount plan and hoping I can afford it. I have lost my job yet do not qualify for disability. Do I think these medications should be made available for those who wish to enhance their ability to learn? Sure. But what I really want is a medication that is affordable so I can drive and hold down a job.


I am sorry to hear that. Likewise, I think healthcare, and medications should be much more affordable (if not free) to those who need them.

Mildly related to this thread, have you tried adrafinil? I have a problem with falling asleep as soon as i hit highways (even with 64 ounces of monster over 3 hours) and I tried adrafinil and it was very effective. I don’t presume to understand your situation, but thought I would offer something to try. Adrafinil is readily available at online retailers and not regulated like modafinil and nuvigil. Adrafinil metabolizes in the body into modafinil. It is harder on the liver though.


Are you familiar with this program?


That sucks. Does Nuvigil actually work for you, though? It’s just an enantiomerically pure version of modafinil/provigil, which is racemic. That is to say–Provigil/modafinil is Nuvigil, but with a mirror image twin of the Nuvigil molecule in the mix as. (And that mirrored twin might do anything ranging from being inert, reduce effect of the drug, or even improve effectiveness; with modafinil I don’t think it’s proven which.)

The research barely shows a better effect with Nuvigil over Provigil. Mainly it’s a differently timed effect. However the cost is much higher (last I checked). But you know what works for you. Just checking to make sure you couldn’t be saving some money.

Also, have you tried Strattera? It was supposed to be a an anti-depressant, and then an ADHD drug. It sort of failed at those, and was demoted to tier 3 or less by most insurance. But it’s been gaining in popularity for excessive sleepiness. It’s also pricey and rarely covered well. But Lilly has a very cheap year discount card you can get. I would try it if I were you, and your physician ok’d it. (But keep the dosages very low, at least to start. The suggested doses were developed to find efficacy for ADHD and seem to be much higher than they should’ve been.)


Yes, the Nuvigil works for me most of the time. I still crash on it, but only once or twice a month. Right now I’m unemployed and out of money, so it’s difficult to say how I would react once back at a job. Modafinil was the precursor to Nuvigil. Nuvigil sharpens my brain and makes me much more alert. I’m on the highest dose my doctor has ever given. I would love to find a better sleep specialist, but with bad insurance, there’s not much I can do.

I have not heard of Strattera. I’ve tried Ritalin, which really didn’t work, either. There’s also an antibiotic that is helping a lot of people with Hypersomnia. But I don’t want to take an antibiotic if I don’t have to.


I will take a look at Adrafinil. The way doctors often treat hypersomnia (which is what I have) is that you get the “all day” pill - Nuvigil for me. And then a short acting 4 hour pill for driving. So I was instructed to take Ritalin in order to drive home. But, it honestly didn’t work. It was difficult getting diagnosed because my sleep doctor kept telling me to just drink more caffeine. Seriously, if that worked, I wouldn’t have been going to the doctor.

Oh, and I do worry about my liver! So maybe that’s not the best thing.