I read that a while ago, it was utter bullshit.
Essentially, the symptoms he complains of are well known as the symptoms of low choline levels, and the drug immediately drops your choline levels like a rock, especially when you first start taking them before your body has adjusted. The reports are either from people with extremely low choline levels, or reporting symptoms of choline overdose.
Some other reports sound like extreme overdoses of the drug, taking it WAY too much and too frequently. Some of them were clearly getting a build up in their system and couldn't figure it out. I've been taking Piracetam, Aniracetam for about 8 months now with 0 negative effects. I take about 1-2 rest days a week during the weekends, no negative effects. Another factor worthy of consideration is the small number of reports of issues and the massive reports of successes.
In 2011 I took the Matrix part of an IQ test and scored about 116, I did another one about a month ago and scored 152. It is a narrow metric, but it was the lowest scoring part of a generalized IQ test I took so I was curious about changes in that particular factor.
There is another issue with those who are excessively stressed. If you take a stressed out, struggling brain and put it under more stress to perform, it isn't going to do better. You have to be not running stimulants 24/7, you have to actually eat and sleep, etc.
I also call bullshit on pretty much everything he wrote. He flat out lied about science, studies and their validity and his so called reports aren't actually sourced.
Lastly, I have my own experience to back me up. I've been in college for five years, I graduate in a month. I've taken 4 semesters in that time with a full 18 credit hours. The first 2 times I got mostly Cs, Maybe 1 B and 1-2 Ds or Fs.
Well, this spring I took 18 credit hours across 8 classes, and I got a 3.4, the highest GPA in my college career. The tests were easy, the homework was easy, life was easy. Everything has just been happier, brighter, easier since I started nootropics. It used to be that I had to study, but I went into tests without studying and got the highest scores in the class.