The three generally accepted “satiety” hormones are: Cholecystokinin, Ghrelin, and Leptin
Cholecystokinin (CCK) seems simple enough. When the small intestine detects macronutrients CCK is released, binding to CCK receptors throughout the nervous system, mediating digestion and satiety.
Leptin similarly inhibits hunger, but over the long term rather than short term like CCK. It is produced by adipose tissue and seems to counteract a few neurotransmitters that increase hunger. The name of the game is decreasing the activity of the neurons in the Arcuate nucleus of the brain.
Ghrelin stimulates hunger by stimulating the Arcuate nucleus and seems to be primarily responsible for the “reward” feeling from good food, and alcohol. It is released by the stomach and pancreas, but how exactly is this triggered?
Is is possible a micronutrient deficiency causes hunger? What is the biological mechanism for this?